OHDSI COVID-19 Studyathon: International coronavirus disease (COVID) - angiotensin converting enzyme (ACE) Receptor Inhibition Utilization and Safety (ICARIUS) studies: susceptibility and severity

Marc Suchard, Seng Chan You, Mitchell Conover

Last updated on Oct 16, 2020

Start Date: Mar 26, 2020

Identifier: EUPAS35296 Study Protocol Forum Discussion

This study will evaluate the effect of ACE inhibitor or ARB exposure on the risk of contracting COVID-19 infection and the risk of experiencing respiratory failure, pneumonia, acute kidney injury, and death in hypertensive patients following contracting COVID-19 infection. The analysis will be undertaken across a federated multi-national network of electronic health records and administrative claims from primary care and secondary care that have been mapped to the Observational Medical Outcomes Partnership Common Data Model in collaboration with the Observational Health Data Sciences and Informatics (OHDSI) and European Health Data and Evidence Network (EHDEN) initiatives. These data reflect the clinical experience of patients from six European countries (Belgium, Netherlands, Germany, France, Spain, and Estonia) the United Kingdom, the United States of America, South Korea, and Japan as data becomes available. We will use a prevalent user cohort design to estimate the relative risk of each outcome using an on-treatment analysis of monotherapy only and monotherapy or combo-therapy comparisons. In the analysis of respiratory failure, pneumonia, acute kidney injury, and death, we will conduct separate analyses assessing prevalent use of antihypertensives at the time of any diagnosis with COVID-19 or at the time of an inpatient admission with COVID-19 diagnosis. Data driven approaches will be used to identify potential covariates for inclusion in matched or stratified propensity score models identified using regularized logistic regression. Large-scale propensity score matching and stratification strategies that allow balancing on a large number of baseline potential confounders will be used in addition to negative control outcomes to allow for evaluating residual bias in the study design as a whole as a diagnostic step.

Event: OHDSI COVID-19 studyathon (2020-03-26 to 2020-03-29) at Microsoft Teams, Organizer: OHDSI

Drugs

benazepril (descendants included)
captopril (descendants included)
cilazapril (descendants included)
enalapril (descendants included)
enalaprilat (descendants included)
fosinopril (descendants included)
fosinoprilat (descendants included)
imidapril (descendants included)
lisinopril (descendants included)
moexipril (descendants included)
moexiprilat (descendants included)
perindopril (descendants included)
perindoprilat (descendants included)
quinapril (descendants included)
quinaprilat (descendants included)
ramipril (descendants included)
ramiprilat (descendants included)
spirapril (descendants included)
trandolapril (descendants included)
trandolaprilat (descendants included)
zofenopril (descendants included)
azilsartan (descendants included)
candesartan (descendants included)
eprosartan (descendants included)
irbesartan (descendants included)
losartan (descendants included)
olmesartan (descendants included)
telmisartan (descendants included)
valsartan (descendants included)
bendroflumethiazide (descendants included)
chlorthalidone (descendants included)
hydrochlorothiazide (descendants included)
indapamide (descendants included)
metolazone (descendants included)
xipamide (descendants included)
amlodipine (descendants included)
clevidipine (descendants included)
felodipine (descendants included)
isradipine (descendants included)
lacidipine (descendants included)
lercanidipine (descendants included)
manidipine (descendants included)
mepirodipine (descendants included)
nicardipine (descendants included)
nifedipine (descendants included)
nilvadipine (descendants included)
nimodipine (descendants included)
nisoldipine (descendants included)
nitrendipine (descendants included)
azilsartan (descendants included)
benazepril (descendants included)
candesartan (descendants included)
captopril (descendants included)
cilazapril (descendants included)
enalapril (descendants included)
enalaprilat (descendants included)
eprosartan (descendants included)
fosinopril (descendants included)
fosinoprilat (descendants included)
imidapril (descendants included)
irbesartan (descendants included)
lisinopril (descendants included)
losartan (descendants included)
moexipril (descendants included)
moexiprilat (descendants included)
olmesartan (descendants included)
perindopril (descendants included)
perindoprilat (descendants included)
quinapril (descendants included)
quinaprilat (descendants included)
ramipril (descendants included)
ramiprilat (descendants included)
spirapril (descendants included)
telmisartan (descendants included)
trandolapril (descendants included)
trandolaprilat (descendants included)
valsartan (descendants included)
zofenopril (descendants included)
benazepril (descendants included)
captopril (descendants included)
cilazapril (descendants included)
enalapril (descendants included)
enalaprilat (descendants included)
fosinopril (descendants included)
fosinoprilat (descendants included)
imidapril (descendants included)
lisinopril (descendants included)
moexipril (descendants included)
moexiprilat (descendants included)
perindopril (descendants included)
perindoprilat (descendants included)
quinapril (descendants included)
quinaprilat (descendants included)
ramipril (descendants included)
ramiprilat (descendants included)
spirapril (descendants included)
trandolapril (descendants included)
trandolaprilat (descendants included)
zofenopril (descendants included)
azilsartan (descendants included)
candesartan (descendants included)
eprosartan (descendants included)
irbesartan (descendants included)
losartan (descendants included)
olmesartan (descendants included)
telmisartan (descendants included)
valsartan (descendants included)
bendroflumethiazide (descendants included)
chlorthalidone (descendants included)
hydrochlorothiazide (descendants included)
indapamide (descendants included)
metolazone (descendants included)
xipamide (descendants included)
amlodipine (descendants included)
clevidipine (descendants included)
felodipine (descendants included)
isradipine (descendants included)
lacidipine (descendants included)
lercanidipine (descendants included)
manidipine (descendants included)
mepirodipine (descendants included)
nicardipine (descendants included)
nifedipine (descendants included)
nilvadipine (descendants included)
nimodipine (descendants included)
nisoldipine (descendants included)
nitrendipine (descendants included)
azilsartan (descendants included)
benazepril (descendants included)
candesartan (descendants included)
captopril (descendants included)
cilazapril (descendants included)
enalapril (descendants included)
enalaprilat (descendants included)
eprosartan (descendants included)
fosinopril (descendants included)
fosinoprilat (descendants included)
imidapril (descendants included)
irbesartan (descendants included)
lisinopril (descendants included)
losartan (descendants included)
moexipril (descendants included)
moexiprilat (descendants included)
olmesartan (descendants included)
perindopril (descendants included)
perindoprilat (descendants included)
quinapril (descendants included)
quinaprilat (descendants included)
ramipril (descendants included)
ramiprilat (descendants included)
spirapril (descendants included)
telmisartan (descendants included)
trandolapril (descendants included)
trandolaprilat (descendants included)
valsartan (descendants included)
zofenopril (descendants included)
benazepril (descendants included)
captopril (descendants included)
cilazapril (descendants included)
enalapril (descendants included)
enalaprilat (descendants included)
fosinopril (descendants included)
fosinoprilat (descendants included)
imidapril (descendants included)
lisinopril (descendants included)
moexipril (descendants included)
moexiprilat (descendants included)
perindopril (descendants included)
perindoprilat (descendants included)
quinapril (descendants included)
quinaprilat (descendants included)
ramipril (descendants included)
ramiprilat (descendants included)
spirapril (descendants included)
trandolapril (descendants included)
trandolaprilat (descendants included)
zofenopril (descendants included)
azilsartan (descendants included)
candesartan (descendants included)
eprosartan (descendants included)
irbesartan (descendants included)
losartan (descendants included)
olmesartan (descendants included)
telmisartan (descendants included)
valsartan (descendants included)
amlodipine (descendants included)
clevidipine (descendants included)
felodipine (descendants included)
isradipine (descendants included)
lacidipine (descendants included)
lercanidipine (descendants included)
manidipine (descendants included)
mepirodipine (descendants included)
nicardipine (descendants included)
nifedipine (descendants included)
nilvadipine (descendants included)
nimodipine (descendants included)
nisoldipine (descendants included)
nitrendipine (descendants included)
diltiazem (descendants included)
gallopamil (descendants included)
verapamil (descendants included)
acebutolol (descendants included)
alprenolol (descendants included)
atenolol (descendants included)
betaxolol (descendants included)
bisoprolol (descendants included)
bopindolol (descendants included)
bupranolol (descendants included)
carteolol (descendants included)
carvedilol (descendants included)
celiprolol (descendants included)
esmolol (descendants included)
labetalol (descendants included)
levobunolol (descendants included)
metipranolol (descendants included)
metoprolol (descendants included)
nadolol (descendants included)
nebivolol (descendants included)
oxprenolol (descendants included)
penbutolol (descendants included)
pindolol (descendants included)
propranolol (descendants included)
sotalol (descendants included)
talinolol (descendants included)
tertatolol (descendants included)
timolol (descendants included)
bendroflumethiazide (descendants included)
chlorthalidone (descendants included)
hydrochlorothiazide (descendants included)
indapamide (descendants included)
metolazone (descendants included)
xipamide (descendants included)
amiloride (descendants included)
bumetanide (descendants included)
eplerenone (descendants included)
furosemide (descendants included)
spironolactone (descendants included)
torsemide (descendants included)
triamterene (descendants included)
azilsartan (descendants included)
candesartan (descendants included)
eprosartan (descendants included)
irbesartan (descendants included)
losartan (descendants included)
olmesartan (descendants included)
telmisartan (descendants included)
valsartan (descendants included)
benazepril (descendants included)
captopril (descendants included)
cilazapril (descendants included)
enalapril (descendants included)
enalaprilat (descendants included)
fosinopril (descendants included)
fosinoprilat (descendants included)
imidapril (descendants included)
lisinopril (descendants included)
moexipril (descendants included)
moexiprilat (descendants included)
perindopril (descendants included)
perindoprilat (descendants included)
quinapril (descendants included)
quinaprilat (descendants included)
ramipril (descendants included)
ramiprilat (descendants included)
spirapril (descendants included)
trandolapril (descendants included)
trandolaprilat (descendants included)
zofenopril (descendants included)
amlodipine (descendants included)
clevidipine (descendants included)
felodipine (descendants included)
isradipine (descendants included)
lacidipine (descendants included)
lercanidipine (descendants included)
manidipine (descendants included)
mepirodipine (descendants included)
nicardipine (descendants included)
nifedipine (descendants included)
nilvadipine (descendants included)
nimodipine (descendants included)
nisoldipine (descendants included)
nitrendipine (descendants included)
diltiazem (descendants included)
gallopamil (descendants included)
verapamil (descendants included)
acebutolol (descendants included)
alprenolol (descendants included)
atenolol (descendants included)
betaxolol (descendants included)
bisoprolol (descendants included)
bopindolol (descendants included)
bupranolol (descendants included)
carteolol (descendants included)
carvedilol (descendants included)
celiprolol (descendants included)
esmolol (descendants included)
labetalol (descendants included)
levobunolol (descendants included)
metipranolol (descendants included)
metoprolol (descendants included)
nadolol (descendants included)
nebivolol (descendants included)
oxprenolol (descendants included)
penbutolol (descendants included)
pindolol (descendants included)
propranolol (descendants included)
sotalol (descendants included)
talinolol (descendants included)
tertatolol (descendants included)
timolol (descendants included)
bendroflumethiazide (descendants included)
chlorthalidone (descendants included)
hydrochlorothiazide (descendants included)
indapamide (descendants included)
metolazone (descendants included)
xipamide (descendants included)
amiloride (descendants included)
bumetanide (descendants included)
eplerenone (descendants included)
furosemide (descendants included)
spironolactone (descendants included)
torsemide (descendants included)
triamterene (descendants included)
bendroflumethiazide (descendants included)
chlorthalidone (descendants included)
hydrochlorothiazide (descendants included)
indapamide (descendants included)
metolazone (descendants included)
xipamide (descendants included)
benazepril (descendants included)
captopril (descendants included)
cilazapril (descendants included)
enalapril (descendants included)
enalaprilat (descendants included)
fosinopril (descendants included)
fosinoprilat (descendants included)
imidapril (descendants included)
lisinopril (descendants included)
moexipril (descendants included)
moexiprilat (descendants included)
perindopril (descendants included)
perindoprilat (descendants included)
quinapril (descendants included)
quinaprilat (descendants included)
ramipril (descendants included)
ramiprilat (descendants included)
spirapril (descendants included)
trandolapril (descendants included)
trandolaprilat (descendants included)
zofenopril (descendants included)
azilsartan (descendants included)
candesartan (descendants included)
eprosartan (descendants included)
irbesartan (descendants included)
losartan (descendants included)
olmesartan (descendants included)
telmisartan (descendants included)
valsartan (descendants included)
amlodipine (descendants included)
clevidipine (descendants included)
felodipine (descendants included)
isradipine (descendants included)
lacidipine (descendants included)
lercanidipine (descendants included)
manidipine (descendants included)
mepirodipine (descendants included)
nicardipine (descendants included)
nifedipine (descendants included)
nilvadipine (descendants included)
nimodipine (descendants included)
nisoldipine (descendants included)
nitrendipine (descendants included)
diltiazem (descendants included)
gallopamil (descendants included)
verapamil (descendants included)
acebutolol (descendants included)
alprenolol (descendants included)
atenolol (descendants included)
betaxolol (descendants included)
bisoprolol (descendants included)
bopindolol (descendants included)
bupranolol (descendants included)
carteolol (descendants included)
carvedilol (descendants included)
celiprolol (descendants included)
esmolol (descendants included)
labetalol (descendants included)
levobunolol (descendants included)
metipranolol (descendants included)
metoprolol (descendants included)
nadolol (descendants included)
nebivolol (descendants included)
oxprenolol (descendants included)
penbutolol (descendants included)
pindolol (descendants included)
propranolol (descendants included)
sotalol (descendants included)
talinolol (descendants included)
tertatolol (descendants included)
timolol (descendants included)
amiloride (descendants included)
bumetanide (descendants included)
eplerenone (descendants included)
furosemide (descendants included)
spironolactone (descendants included)
torsemide (descendants included)
triamterene (descendants included)
amlodipine (descendants included)
clevidipine (descendants included)
felodipine (descendants included)
isradipine (descendants included)
lacidipine (descendants included)
lercanidipine (descendants included)
manidipine (descendants included)
mepirodipine (descendants included)
nicardipine (descendants included)
nifedipine (descendants included)
nilvadipine (descendants included)
nimodipine (descendants included)
nisoldipine (descendants included)
nitrendipine (descendants included)
benazepril (descendants included)
captopril (descendants included)
cilazapril (descendants included)
enalapril (descendants included)
enalaprilat (descendants included)
fosinopril (descendants included)
fosinoprilat (descendants included)
imidapril (descendants included)
lisinopril (descendants included)
moexipril (descendants included)
moexiprilat (descendants included)
perindopril (descendants included)
perindoprilat (descendants included)
quinapril (descendants included)
quinaprilat (descendants included)
ramipril (descendants included)
ramiprilat (descendants included)
spirapril (descendants included)
trandolapril (descendants included)
trandolaprilat (descendants included)
zofenopril (descendants included)
azilsartan (descendants included)
candesartan (descendants included)
eprosartan (descendants included)
irbesartan (descendants included)
losartan (descendants included)
olmesartan (descendants included)
telmisartan (descendants included)
valsartan (descendants included)
diltiazem (descendants included)
gallopamil (descendants included)
verapamil (descendants included)
acebutolol (descendants included)
alprenolol (descendants included)
atenolol (descendants included)
betaxolol (descendants included)
bisoprolol (descendants included)
bopindolol (descendants included)
bupranolol (descendants included)
carteolol (descendants included)
carvedilol (descendants included)
celiprolol (descendants included)
esmolol (descendants included)
labetalol (descendants included)
levobunolol (descendants included)
metipranolol (descendants included)
metoprolol (descendants included)
nadolol (descendants included)
nebivolol (descendants included)
oxprenolol (descendants included)
penbutolol (descendants included)
pindolol (descendants included)
propranolol (descendants included)
sotalol (descendants included)
talinolol (descendants included)
tertatolol (descendants included)
timolol (descendants included)
bendroflumethiazide (descendants included)
chlorthalidone (descendants included)
hydrochlorothiazide (descendants included)
indapamide (descendants included)
metolazone (descendants included)
xipamide (descendants included)
amiloride (descendants included)
bumetanide (descendants included)
eplerenone (descendants included)
furosemide (descendants included)
spironolactone (descendants included)
torsemide (descendants included)
triamterene (descendants included)
azilsartan (descendants included)
benazepril (descendants included)
candesartan (descendants included)
captopril (descendants included)
cilazapril (descendants included)
enalapril (descendants included)
enalaprilat (descendants included)
eprosartan (descendants included)
fosinopril (descendants included)
fosinoprilat (descendants included)
imidapril (descendants included)
irbesartan (descendants included)
lisinopril (descendants included)
losartan (descendants included)
moexipril (descendants included)
moexiprilat (descendants included)
olmesartan (descendants included)
perindopril (descendants included)
perindoprilat (descendants included)
quinapril (descendants included)
quinaprilat (descendants included)
ramipril (descendants included)
ramiprilat (descendants included)
spirapril (descendants included)
telmisartan (descendants included)
trandolapril (descendants included)
trandolaprilat (descendants included)
valsartan (descendants included)
zofenopril (descendants included)
amlodipine (descendants included)
clevidipine (descendants included)
felodipine (descendants included)
isradipine (descendants included)
lacidipine (descendants included)
lercanidipine (descendants included)
manidipine (descendants included)
mepirodipine (descendants included)
nicardipine (descendants included)
nifedipine (descendants included)
nilvadipine (descendants included)
nimodipine (descendants included)
nisoldipine (descendants included)
nitrendipine (descendants included)
diltiazem (descendants included)
gallopamil (descendants included)
verapamil (descendants included)
acebutolol (descendants included)
alprenolol (descendants included)
atenolol (descendants included)
betaxolol (descendants included)
bisoprolol (descendants included)
bopindolol (descendants included)
bupranolol (descendants included)
carteolol (descendants included)
carvedilol (descendants included)
celiprolol (descendants included)
esmolol (descendants included)
labetalol (descendants included)
levobunolol (descendants included)
metipranolol (descendants included)
metoprolol (descendants included)
nadolol (descendants included)
nebivolol (descendants included)
oxprenolol (descendants included)
penbutolol (descendants included)
pindolol (descendants included)
propranolol (descendants included)
sotalol (descendants included)
talinolol (descendants included)
tertatolol (descendants included)
timolol (descendants included)
bendroflumethiazide (descendants included)
chlorthalidone (descendants included)
hydrochlorothiazide (descendants included)
indapamide (descendants included)
metolazone (descendants included)
xipamide (descendants included)
amiloride (descendants included)
bumetanide (descendants included)
eplerenone (descendants included)
furosemide (descendants included)
spironolactone (descendants included)
torsemide (descendants included)
triamterene (descendants included)
benazepril (descendants included)
captopril (descendants included)
cilazapril (descendants included)
enalapril (descendants included)
enalaprilat (descendants included)
fosinopril (descendants included)
fosinoprilat (descendants included)
imidapril (descendants included)
lisinopril (descendants included)
moexipril (descendants included)
moexiprilat (descendants included)
perindopril (descendants included)
perindoprilat (descendants included)
quinapril (descendants included)
quinaprilat (descendants included)
ramipril (descendants included)
ramiprilat (descendants included)
spirapril (descendants included)
trandolapril (descendants included)
trandolaprilat (descendants included)
zofenopril (descendants included)
azilsartan (descendants included)
candesartan (descendants included)
eprosartan (descendants included)
irbesartan (descendants included)
losartan (descendants included)
olmesartan (descendants included)
telmisartan (descendants included)
valsartan (descendants included)
amlodipine (descendants included)
bendroflumethiazide (descendants included)
chlorthalidone (descendants included)
clevidipine (descendants included)
felodipine (descendants included)
hydrochlorothiazide (descendants included)
indapamide (descendants included)
isradipine (descendants included)
lacidipine (descendants included)
lercanidipine (descendants included)
manidipine (descendants included)
mepirodipine (descendants included)
metolazone (descendants included)
nicardipine (descendants included)
nifedipine (descendants included)
nilvadipine (descendants included)
nimodipine (descendants included)
nisoldipine (descendants included)
nitrendipine (descendants included)
xipamide (descendants included)
diltiazem (descendants included)
gallopamil (descendants included)
verapamil (descendants included)
acebutolol (descendants included)
alprenolol (descendants included)
atenolol (descendants included)
betaxolol (descendants included)
bisoprolol (descendants included)
bopindolol (descendants included)
bupranolol (descendants included)
carteolol (descendants included)
carvedilol (descendants included)
celiprolol (descendants included)
esmolol (descendants included)
labetalol (descendants included)
levobunolol (descendants included)
metipranolol (descendants included)
metoprolol (descendants included)
nadolol (descendants included)
nebivolol (descendants included)
oxprenolol (descendants included)
penbutolol (descendants included)
pindolol (descendants included)
propranolol (descendants included)
sotalol (descendants included)
talinolol (descendants included)
tertatolol (descendants included)
timolol (descendants included)
bendroflumethiazide (descendants included)
chlorthalidone (descendants included)
hydrochlorothiazide (descendants included)
indapamide (descendants included)
metolazone (descendants included)
xipamide (descendants included)
amiloride (descendants included)
bumetanide (descendants included)
eplerenone (descendants included)
furosemide (descendants included)
spironolactone (descendants included)
torsemide (descendants included)
triamterene (descendants included)
azilsartan (descendants included)
candesartan (descendants included)
eprosartan (descendants included)
irbesartan (descendants included)
losartan (descendants included)
olmesartan (descendants included)
telmisartan (descendants included)
valsartan (descendants included)
benazepril (descendants included)
captopril (descendants included)
cilazapril (descendants included)
enalapril (descendants included)
enalaprilat (descendants included)
fosinopril (descendants included)
fosinoprilat (descendants included)
imidapril (descendants included)
lisinopril (descendants included)
moexipril (descendants included)
moexiprilat (descendants included)
perindopril (descendants included)
perindoprilat (descendants included)
quinapril (descendants included)
quinaprilat (descendants included)
ramipril (descendants included)
ramiprilat (descendants included)
spirapril (descendants included)
trandolapril (descendants included)
trandolaprilat (descendants included)
zofenopril (descendants included)
amlodipine (descendants included)
clevidipine (descendants included)
felodipine (descendants included)
isradipine (descendants included)
lacidipine (descendants included)
lercanidipine (descendants included)
manidipine (descendants included)
mepirodipine (descendants included)
nicardipine (descendants included)
nifedipine (descendants included)
nilvadipine (descendants included)
nimodipine (descendants included)
nisoldipine (descendants included)
nitrendipine (descendants included)
diltiazem (descendants included)
gallopamil (descendants included)
verapamil (descendants included)
acebutolol (descendants included)
alprenolol (descendants included)
atenolol (descendants included)
betaxolol (descendants included)
bisoprolol (descendants included)
bopindolol (descendants included)
bupranolol (descendants included)
carteolol (descendants included)
carvedilol (descendants included)
celiprolol (descendants included)
esmolol (descendants included)
labetalol (descendants included)
levobunolol (descendants included)
metipranolol (descendants included)
metoprolol (descendants included)
nadolol (descendants included)
nebivolol (descendants included)
oxprenolol (descendants included)
penbutolol (descendants included)
pindolol (descendants included)
propranolol (descendants included)
sotalol (descendants included)
talinolol (descendants included)
tertatolol (descendants included)
timolol (descendants included)
bendroflumethiazide (descendants included)
chlorthalidone (descendants included)
hydrochlorothiazide (descendants included)
indapamide (descendants included)
metolazone (descendants included)
xipamide (descendants included)
amiloride (descendants included)
bumetanide (descendants included)
eplerenone (descendants included)
furosemide (descendants included)
spironolactone (descendants included)
torsemide (descendants included)
triamterene (descendants included)
bendroflumethiazide (descendants included)
chlorthalidone (descendants included)
hydrochlorothiazide (descendants included)
indapamide (descendants included)
metolazone (descendants included)
xipamide (descendants included)
benazepril (descendants included)
captopril (descendants included)
cilazapril (descendants included)
enalapril (descendants included)
enalaprilat (descendants included)
fosinopril (descendants included)
fosinoprilat (descendants included)
imidapril (descendants included)
lisinopril (descendants included)
moexipril (descendants included)
moexiprilat (descendants included)
perindopril (descendants included)
perindoprilat (descendants included)
quinapril (descendants included)
quinaprilat (descendants included)
ramipril (descendants included)
ramiprilat (descendants included)
spirapril (descendants included)
trandolapril (descendants included)
trandolaprilat (descendants included)
zofenopril (descendants included)
azilsartan (descendants included)
candesartan (descendants included)
eprosartan (descendants included)
irbesartan (descendants included)
losartan (descendants included)
olmesartan (descendants included)
telmisartan (descendants included)
valsartan (descendants included)
amlodipine (descendants included)
clevidipine (descendants included)
felodipine (descendants included)
isradipine (descendants included)
lacidipine (descendants included)
lercanidipine (descendants included)
manidipine (descendants included)
mepirodipine (descendants included)
nicardipine (descendants included)
nifedipine (descendants included)
nilvadipine (descendants included)
nimodipine (descendants included)
nisoldipine (descendants included)
nitrendipine (descendants included)
diltiazem (descendants included)
gallopamil (descendants included)
verapamil (descendants included)
acebutolol (descendants included)
alprenolol (descendants included)
atenolol (descendants included)
betaxolol (descendants included)
bisoprolol (descendants included)
bopindolol (descendants included)
bupranolol (descendants included)
carteolol (descendants included)
carvedilol (descendants included)
celiprolol (descendants included)
esmolol (descendants included)
labetalol (descendants included)
levobunolol (descendants included)
metipranolol (descendants included)
metoprolol (descendants included)
nadolol (descendants included)
nebivolol (descendants included)
oxprenolol (descendants included)
penbutolol (descendants included)
pindolol (descendants included)
propranolol (descendants included)
sotalol (descendants included)
talinolol (descendants included)
tertatolol (descendants included)
timolol (descendants included)
amiloride (descendants included)
bumetanide (descendants included)
eplerenone (descendants included)
furosemide (descendants included)
spironolactone (descendants included)
torsemide (descendants included)
triamterene (descendants included)
amlodipine (descendants included)
clevidipine (descendants included)
felodipine (descendants included)
isradipine (descendants included)
lacidipine (descendants included)
lercanidipine (descendants included)
manidipine (descendants included)
mepirodipine (descendants included)
nicardipine (descendants included)
nifedipine (descendants included)
nilvadipine (descendants included)
nimodipine (descendants included)
nisoldipine (descendants included)
nitrendipine (descendants included)
benazepril (descendants included)
captopril (descendants included)
cilazapril (descendants included)
enalapril (descendants included)
enalaprilat (descendants included)
fosinopril (descendants included)
fosinoprilat (descendants included)
imidapril (descendants included)
lisinopril (descendants included)
moexipril (descendants included)
moexiprilat (descendants included)
perindopril (descendants included)
perindoprilat (descendants included)
quinapril (descendants included)
quinaprilat (descendants included)
ramipril (descendants included)
ramiprilat (descendants included)
spirapril (descendants included)
trandolapril (descendants included)
trandolaprilat (descendants included)
zofenopril (descendants included)
azilsartan (descendants included)
candesartan (descendants included)
eprosartan (descendants included)
irbesartan (descendants included)
losartan (descendants included)
olmesartan (descendants included)
telmisartan (descendants included)
valsartan (descendants included)
diltiazem (descendants included)
gallopamil (descendants included)
verapamil (descendants included)
acebutolol (descendants included)
alprenolol (descendants included)
atenolol (descendants included)
betaxolol (descendants included)
bisoprolol (descendants included)
bopindolol (descendants included)
bupranolol (descendants included)
carteolol (descendants included)
carvedilol (descendants included)
celiprolol (descendants included)
esmolol (descendants included)
labetalol (descendants included)
levobunolol (descendants included)
metipranolol (descendants included)
metoprolol (descendants included)
nadolol (descendants included)
nebivolol (descendants included)
oxprenolol (descendants included)
penbutolol (descendants included)
pindolol (descendants included)
propranolol (descendants included)
sotalol (descendants included)
talinolol (descendants included)
tertatolol (descendants included)
timolol (descendants included)
bendroflumethiazide (descendants included)
chlorthalidone (descendants included)
hydrochlorothiazide (descendants included)
indapamide (descendants included)
metolazone (descendants included)
xipamide (descendants included)
amiloride (descendants included)
bumetanide (descendants included)
eplerenone (descendants included)
furosemide (descendants included)
spironolactone (descendants included)
torsemide (descendants included)
triamterene (descendants included)
azilsartan (descendants included)
benazepril (descendants included)
candesartan (descendants included)
captopril (descendants included)
cilazapril (descendants included)
enalapril (descendants included)
enalaprilat (descendants included)
eprosartan (descendants included)
fosinopril (descendants included)
fosinoprilat (descendants included)
imidapril (descendants included)
irbesartan (descendants included)
lisinopril (descendants included)
losartan (descendants included)
moexipril (descendants included)
moexiprilat (descendants included)
olmesartan (descendants included)
perindopril (descendants included)
perindoprilat (descendants included)
quinapril (descendants included)
quinaprilat (descendants included)
ramipril (descendants included)
ramiprilat (descendants included)
spirapril (descendants included)
telmisartan (descendants included)
trandolapril (descendants included)
trandolaprilat (descendants included)
valsartan (descendants included)
zofenopril (descendants included)
amlodipine (descendants included)
clevidipine (descendants included)
felodipine (descendants included)
isradipine (descendants included)
lacidipine (descendants included)
lercanidipine (descendants included)
manidipine (descendants included)
mepirodipine (descendants included)
nicardipine (descendants included)
nifedipine (descendants included)
nilvadipine (descendants included)
nimodipine (descendants included)
nisoldipine (descendants included)
nitrendipine (descendants included)
diltiazem (descendants included)
gallopamil (descendants included)
verapamil (descendants included)
acebutolol (descendants included)
alprenolol (descendants included)
atenolol (descendants included)
betaxolol (descendants included)
bisoprolol (descendants included)
bopindolol (descendants included)
bupranolol (descendants included)
carteolol (descendants included)
carvedilol (descendants included)
celiprolol (descendants included)
esmolol (descendants included)
labetalol (descendants included)
levobunolol (descendants included)
metipranolol (descendants included)
metoprolol (descendants included)
nadolol (descendants included)
nebivolol (descendants included)
oxprenolol (descendants included)
penbutolol (descendants included)
pindolol (descendants included)
propranolol (descendants included)
sotalol (descendants included)
talinolol (descendants included)
tertatolol (descendants included)
timolol (descendants included)
bendroflumethiazide (descendants included)
chlorthalidone (descendants included)
hydrochlorothiazide (descendants included)
indapamide (descendants included)
metolazone (descendants included)
xipamide (descendants included)
amiloride (descendants included)
bumetanide (descendants included)
eplerenone (descendants included)
furosemide (descendants included)
spironolactone (descendants included)
torsemide (descendants included)
triamterene (descendants included)
amlodipine (descendants included)
bendroflumethiazide (descendants included)
chlorthalidone (descendants included)
clevidipine (descendants included)
felodipine (descendants included)
hydrochlorothiazide (descendants included)
indapamide (descendants included)
isradipine (descendants included)
lacidipine (descendants included)
lercanidipine (descendants included)
manidipine (descendants included)
mepirodipine (descendants included)
metolazone (descendants included)
nicardipine (descendants included)
nifedipine (descendants included)
nilvadipine (descendants included)
nimodipine (descendants included)
nisoldipine (descendants included)
nitrendipine (descendants included)
xipamide (descendants included)
benazepril (descendants included)
captopril (descendants included)
cilazapril (descendants included)
enalapril (descendants included)
enalaprilat (descendants included)
fosinopril (descendants included)
fosinoprilat (descendants included)
imidapril (descendants included)
lisinopril (descendants included)
moexipril (descendants included)
moexiprilat (descendants included)
perindopril (descendants included)
perindoprilat (descendants included)
quinapril (descendants included)
quinaprilat (descendants included)
ramipril (descendants included)
ramiprilat (descendants included)
spirapril (descendants included)
trandolapril (descendants included)
trandolaprilat (descendants included)
zofenopril (descendants included)
azilsartan (descendants included)
candesartan (descendants included)
eprosartan (descendants included)
irbesartan (descendants included)
losartan (descendants included)
olmesartan (descendants included)
telmisartan (descendants included)
valsartan (descendants included)
diltiazem (descendants included)
gallopamil (descendants included)
verapamil (descendants included)
acebutolol (descendants included)
alprenolol (descendants included)
atenolol (descendants included)
betaxolol (descendants included)
bisoprolol (descendants included)
bopindolol (descendants included)
bupranolol (descendants included)
carteolol (descendants included)
carvedilol (descendants included)
celiprolol (descendants included)
esmolol (descendants included)
labetalol (descendants included)
levobunolol (descendants included)
metipranolol (descendants included)
metoprolol (descendants included)
nadolol (descendants included)
nebivolol (descendants included)
oxprenolol (descendants included)
penbutolol (descendants included)
pindolol (descendants included)
propranolol (descendants included)
sotalol (descendants included)
talinolol (descendants included)
tertatolol (descendants included)
timolol (descendants included)
amiloride (descendants included)
bumetanide (descendants included)
eplerenone (descendants included)
furosemide (descendants included)
spironolactone (descendants included)
torsemide (descendants included)
triamterene (descendants included)
amlodipine (descendants included)
bendroflumethiazide (descendants included)
chlorthalidone (descendants included)
clevidipine (descendants included)
felodipine (descendants included)
hydrochlorothiazide (descendants included)
indapamide (descendants included)
isradipine (descendants included)
lacidipine (descendants included)
lercanidipine (descendants included)
manidipine (descendants included)
mepirodipine (descendants included)
metolazone (descendants included)
nicardipine (descendants included)
nifedipine (descendants included)
nilvadipine (descendants included)
nimodipine (descendants included)
nisoldipine (descendants included)
nitrendipine (descendants included)
xipamide (descendants included)
benazepril (descendants included)
captopril (descendants included)
cilazapril (descendants included)
enalapril (descendants included)
enalaprilat (descendants included)
fosinopril (descendants included)
fosinoprilat (descendants included)
imidapril (descendants included)
lisinopril (descendants included)
moexipril (descendants included)
moexiprilat (descendants included)
perindopril (descendants included)
perindoprilat (descendants included)
quinapril (descendants included)
quinaprilat (descendants included)
ramipril (descendants included)
ramiprilat (descendants included)
spirapril (descendants included)
trandolapril (descendants included)
trandolaprilat (descendants included)
zofenopril (descendants included)
azilsartan (descendants included)
candesartan (descendants included)
eprosartan (descendants included)
irbesartan (descendants included)
losartan (descendants included)
olmesartan (descendants included)
telmisartan (descendants included)
valsartan (descendants included)
diltiazem (descendants included)
gallopamil (descendants included)
verapamil (descendants included)
acebutolol (descendants included)
alprenolol (descendants included)
atenolol (descendants included)
betaxolol (descendants included)
bisoprolol (descendants included)
bopindolol (descendants included)
bupranolol (descendants included)
carteolol (descendants included)
carvedilol (descendants included)
celiprolol (descendants included)
esmolol (descendants included)
labetalol (descendants included)
levobunolol (descendants included)
metipranolol (descendants included)
metoprolol (descendants included)
nadolol (descendants included)
nebivolol (descendants included)
oxprenolol (descendants included)
penbutolol (descendants included)
pindolol (descendants included)
propranolol (descendants included)
sotalol (descendants included)
talinolol (descendants included)
tertatolol (descendants included)
timolol (descendants included)
amiloride (descendants included)
bumetanide (descendants included)
eplerenone (descendants included)
furosemide (descendants included)
spironolactone (descendants included)
torsemide (descendants included)
triamterene (descendants included)
amlodipine (descendants included)
bendroflumethiazide (descendants included)
chlorthalidone (descendants included)
clevidipine (descendants included)
felodipine (descendants included)
hydrochlorothiazide (descendants included)
indapamide (descendants included)
isradipine (descendants included)
lacidipine (descendants included)
lercanidipine (descendants included)
manidipine (descendants included)
mepirodipine (descendants included)
metolazone (descendants included)
nicardipine (descendants included)
nifedipine (descendants included)
nilvadipine (descendants included)
nimodipine (descendants included)
nisoldipine (descendants included)
nitrendipine (descendants included)
xipamide (descendants included)
amlodipine (descendants included)
bendroflumethiazide (descendants included)
chlorthalidone (descendants included)
clevidipine (descendants included)
felodipine (descendants included)
hydrochlorothiazide (descendants included)
indapamide (descendants included)
isradipine (descendants included)
lacidipine (descendants included)
lercanidipine (descendants included)
manidipine (descendants included)
mepirodipine (descendants included)
metolazone (descendants included)
nicardipine (descendants included)
nifedipine (descendants included)
nilvadipine (descendants included)
nimodipine (descendants included)
nisoldipine (descendants included)
nitrendipine (descendants included)
xipamide (descendants included)
Losartan (descendants included)
azilsartan (descendants included)
candesartan (descendants included)
eprosartan (descendants included)
irbesartan (descendants included)
olmesartan (descendants included)
telmisartan (descendants included)
valsartan (descendants included)
Amlodipine (descendants included)
Felodipine (descendants included)
Isradipine (descendants included)
Nicardipine (descendants included)
Nifedipine (descendants included)
Nisoldipine (descendants included)
Captopril (descendants included)
Enalapril (descendants included)
Fosinopril (descendants included)
Lisinopril (descendants included)
Perindopril (descendants included)
Ramipril (descendants included)
benazepril (descendants included)
moexipril (descendants included)
quinapril (descendants included)
trandolapril (descendants included)
Acebutolol (descendants included)
Atenolol (descendants included)
Betaxolol (descendants included)
Bisoprolol (descendants included)
Labetalol (descendants included)
Metoprolol (descendants included)
Nadolol (descendants included)
Penbutolol (descendants included)
Pindolol (descendants included)
Propranolol (descendants included)
carvedilol (descendants included)
nebivolol (descendants included)
Chlorthalidone (descendants included)
Hydrochlorothiazide (descendants included)
Indapamide (descendants included)
Metolazone (descendants included)
Diltiazem (descendants included)
Verapamil (descendants included)
Amiloride (descendants included)
Bumetanide (descendants included)
Furosemide (descendants included)
Spironolactone (descendants included)
Triamterene (descendants included)
eplerenone (descendants included)
torsemide (descendants included)
Captopril (descendants included)
Enalapril (descendants included)
Fosinopril (descendants included)
Lisinopril (descendants included)
Perindopril (descendants included)
Ramipril (descendants included)
benazepril (descendants included)
moexipril (descendants included)
quinapril (descendants included)
trandolapril (descendants included)
Captopril (descendants included)
Enalapril (descendants included)
Fosinopril (descendants included)
Lisinopril (descendants included)
Losartan (descendants included)
Perindopril (descendants included)
Ramipril (descendants included)
azilsartan (descendants included)
benazepril (descendants included)
candesartan (descendants included)
eprosartan (descendants included)
irbesartan (descendants included)
moexipril (descendants included)
olmesartan (descendants included)
quinapril (descendants included)
telmisartan (descendants included)
trandolapril (descendants included)
valsartan (descendants included)
Amlodipine (descendants included)
Felodipine (descendants included)
Isradipine (descendants included)
Nicardipine (descendants included)
Nifedipine (descendants included)
Nisoldipine (descendants included)
Acebutolol (descendants included)
Atenolol (descendants included)
Betaxolol (descendants included)
Bisoprolol (descendants included)
Labetalol (descendants included)
Metoprolol (descendants included)
Nadolol (descendants included)
Penbutolol (descendants included)
Pindolol (descendants included)
Propranolol (descendants included)
carvedilol (descendants included)
nebivolol (descendants included)
Chlorthalidone (descendants included)
Hydrochlorothiazide (descendants included)
Indapamide (descendants included)
Metolazone (descendants included)
Diltiazem (descendants included)
Verapamil (descendants included)
Amiloride (descendants included)
Bumetanide (descendants included)
Furosemide (descendants included)
Spironolactone (descendants included)
Triamterene (descendants included)
eplerenone (descendants included)
torsemide (descendants included)
Captopril (descendants included)
Enalapril (descendants included)
Fosinopril (descendants included)
Lisinopril (descendants included)
Losartan (descendants included)
Perindopril (descendants included)
Ramipril (descendants included)
azilsartan (descendants included)
benazepril (descendants included)
candesartan (descendants included)
eprosartan (descendants included)
irbesartan (descendants included)
moexipril (descendants included)
olmesartan (descendants included)
quinapril (descendants included)
telmisartan (descendants included)
trandolapril (descendants included)
valsartan (descendants included)
Losartan (descendants included)
azilsartan (descendants included)
candesartan (descendants included)
eprosartan (descendants included)
irbesartan (descendants included)
olmesartan (descendants included)
telmisartan (descendants included)
valsartan (descendants included)
Amlodipine (descendants included)
Felodipine (descendants included)
Isradipine (descendants included)
Nicardipine (descendants included)
Nifedipine (descendants included)
Nisoldipine (descendants included)
Captopril (descendants included)
Enalapril (descendants included)
Fosinopril (descendants included)
Lisinopril (descendants included)
Perindopril (descendants included)
Ramipril (descendants included)
benazepril (descendants included)
moexipril (descendants included)
quinapril (descendants included)
trandolapril (descendants included)
Acebutolol (descendants included)
Atenolol (descendants included)
Betaxolol (descendants included)
Bisoprolol (descendants included)
Labetalol (descendants included)
Metoprolol (descendants included)
Nadolol (descendants included)
Penbutolol (descendants included)
Pindolol (descendants included)
Propranolol (descendants included)
carvedilol (descendants included)
nebivolol (descendants included)
Chlorthalidone (descendants included)
Hydrochlorothiazide (descendants included)
Indapamide (descendants included)
Metolazone (descendants included)
Diltiazem (descendants included)
Verapamil (descendants included)
Amiloride (descendants included)
Bumetanide (descendants included)
Furosemide (descendants included)
Spironolactone (descendants included)
Triamterene (descendants included)
eplerenone (descendants included)
torsemide (descendants included)
Losartan (descendants included)
azilsartan (descendants included)
candesartan (descendants included)
eprosartan (descendants included)
irbesartan (descendants included)
olmesartan (descendants included)
telmisartan (descendants included)
valsartan (descendants included)
Losartan (descendants included)
azilsartan (descendants included)
candesartan (descendants included)
eprosartan (descendants included)
irbesartan (descendants included)
olmesartan (descendants included)
telmisartan (descendants included)
valsartan (descendants included)
Amlodipine (descendants included)
Felodipine (descendants included)
Isradipine (descendants included)
Nicardipine (descendants included)
Nifedipine (descendants included)
Nisoldipine (descendants included)
Captopril (descendants included)
Enalapril (descendants included)
Fosinopril (descendants included)
Lisinopril (descendants included)
Perindopril (descendants included)
Ramipril (descendants included)
benazepril (descendants included)
moexipril (descendants included)
quinapril (descendants included)
trandolapril (descendants included)
Acebutolol (descendants included)
Atenolol (descendants included)
Betaxolol (descendants included)
Bisoprolol (descendants included)
Labetalol (descendants included)
Metoprolol (descendants included)
Nadolol (descendants included)
Penbutolol (descendants included)
Pindolol (descendants included)
Propranolol (descendants included)
carvedilol (descendants included)
nebivolol (descendants included)
Chlorthalidone (descendants included)
Hydrochlorothiazide (descendants included)
Indapamide (descendants included)
Metolazone (descendants included)
Diltiazem (descendants included)
Verapamil (descendants included)
Amiloride (descendants included)
Bumetanide (descendants included)
Furosemide (descendants included)
Spironolactone (descendants included)
Triamterene (descendants included)
eplerenone (descendants included)
torsemide (descendants included)
Amlodipine (descendants included)
Felodipine (descendants included)
Isradipine (descendants included)
Nicardipine (descendants included)
Nifedipine (descendants included)
Nisoldipine (descendants included)
Chlorthalidone (descendants included)
Hydrochlorothiazide (descendants included)
Indapamide (descendants included)
Metolazone (descendants included)
Losartan (descendants included)
azilsartan (descendants included)
candesartan (descendants included)
eprosartan (descendants included)
irbesartan (descendants included)
olmesartan (descendants included)
telmisartan (descendants included)
valsartan (descendants included)
Amlodipine (descendants included)
Felodipine (descendants included)
Isradipine (descendants included)
Nicardipine (descendants included)
Nifedipine (descendants included)
Nisoldipine (descendants included)
Captopril (descendants included)
Enalapril (descendants included)
Fosinopril (descendants included)
Lisinopril (descendants included)
Perindopril (descendants included)
Ramipril (descendants included)
benazepril (descendants included)
moexipril (descendants included)
quinapril (descendants included)
trandolapril (descendants included)
Acebutolol (descendants included)
Atenolol (descendants included)
Betaxolol (descendants included)
Bisoprolol (descendants included)
Labetalol (descendants included)
Metoprolol (descendants included)
Nadolol (descendants included)
Penbutolol (descendants included)
Pindolol (descendants included)
Propranolol (descendants included)
carvedilol (descendants included)
nebivolol (descendants included)
Chlorthalidone (descendants included)
Hydrochlorothiazide (descendants included)
Indapamide (descendants included)
Metolazone (descendants included)
Diltiazem (descendants included)
Verapamil (descendants included)
Amiloride (descendants included)
Bumetanide (descendants included)
Furosemide (descendants included)
Spironolactone (descendants included)
Triamterene (descendants included)
eplerenone (descendants included)
torsemide (descendants included)
Acebutolol (descendants included)
Atenolol (descendants included)
Betaxolol (descendants included)
Bisoprolol (descendants included)
Labetalol (descendants included)
Metoprolol (descendants included)
Nadolol (descendants included)
Penbutolol (descendants included)
Pindolol (descendants included)
Propranolol (descendants included)
carvedilol (descendants included)
nebivolol (descendants included)
Diltiazem (descendants included)
Verapamil (descendants included)
Amiloride (descendants included)
Bumetanide (descendants included)
Furosemide (descendants included)
Spironolactone (descendants included)
Triamterene (descendants included)
eplerenone (descendants included)
torsemide (descendants included)
Amlodipine (descendants included)
Chlorthalidone (descendants included)
Felodipine (descendants included)
Hydrochlorothiazide (descendants included)
Indapamide (descendants included)
Isradipine (descendants included)
Metolazone (descendants included)
Nicardipine (descendants included)
Nifedipine (descendants included)
Nisoldipine (descendants included)
Captopril (descendants included)
Enalapril (descendants included)
Fosinopril (descendants included)
Lisinopril (descendants included)
Perindopril (descendants included)
Ramipril (descendants included)
benazepril (descendants included)
moexipril (descendants included)
quinapril (descendants included)
trandolapril (descendants included)
Losartan (descendants included)
azilsartan (descendants included)
candesartan (descendants included)
eprosartan (descendants included)
irbesartan (descendants included)
olmesartan (descendants included)
telmisartan (descendants included)
valsartan (descendants included)
Amlodipine (descendants included)
Chlorthalidone (descendants included)
Felodipine (descendants included)
Hydrochlorothiazide (descendants included)
Indapamide (descendants included)
Isradipine (descendants included)
Metolazone (descendants included)
Nicardipine (descendants included)
Nifedipine (descendants included)
Nisoldipine (descendants included)

Health Conditions

Disease caused by 2019-nCoV (descendants included)
Disease due to Coronaviridae (descendants included)
Coronavirus infection (descendants included)
Hypertensive disorder (descendants included)
Disease caused by 2019-nCoV (descendants included)
Disease due to Coronaviridae (descendants included)
Coronavirus infection (descendants included)
Hypertensive disorder (descendants included)
Disease caused by 2019-nCoV (descendants included)
Disease due to Coronaviridae (descendants included)
Coronavirus infection (descendants included)
Hypertensive disorder (descendants included)
Disease caused by 2019-nCoV (descendants included)
Disease due to Coronaviridae (descendants included)
Coronavirus infection (descendants included)
Hypertensive disorder (descendants included)
Disease caused by 2019-nCoV (descendants included)
Disease due to Coronaviridae (descendants included)
Coronavirus infection (descendants included)
Hypertensive disorder (descendants included)
Disease caused by 2019-nCoV (descendants included)
Disease due to Coronaviridae (descendants included)
Coronavirus infection (descendants included)
Hypertensive disorder (descendants included)
Disease caused by 2019-nCoV (descendants included)
Disease due to Coronaviridae (descendants included)
Coronavirus infection (descendants included)
Hypertensive disorder (descendants included)
Disease caused by 2019-nCoV (descendants included)
Disease due to Coronaviridae (descendants included)
Coronavirus infection (descendants included)
Hypertensive disorder (descendants included)
Disease caused by 2019-nCoV (descendants included)
Disease due to Coronaviridae (descendants included)
Coronavirus infection (descendants included)
Hypertensive disorder (descendants included)
Disease caused by 2019-nCoV (descendants included)
Disease due to Coronaviridae (descendants included)
Coronavirus infection (descendants included)
Hypertensive disorder (descendants included)
Disease caused by 2019-nCoV (descendants included)
Disease due to Coronaviridae (descendants included)
Coronavirus infection (descendants included)
Hypertensive disorder (descendants included)
Disease caused by 2019-nCoV (descendants included)
Disease due to Coronaviridae (descendants included)
Coronavirus infection (descendants included)
Hypertensive disorder (descendants included)
Disease caused by 2019-nCoV (descendants included)
Disease due to Coronaviridae (descendants included)
Coronavirus infection (descendants included)
Hypertensive disorder (descendants included)
Disease caused by 2019-nCoV (descendants included)
Disease due to Coronaviridae (descendants included)
Coronavirus infection (descendants included)
Hypertensive disorder (descendants included)
Disease caused by 2019-nCoV (descendants included)
Disease due to Coronaviridae (descendants included)
Coronavirus infection (descendants included)
Hypertensive disorder (descendants included)
Disease caused by 2019-nCoV (descendants included)
Disease due to Coronaviridae (descendants included)
Coronavirus infection (descendants included)
Hypertensive disorder (descendants included)
Disease caused by 2019-nCoV (descendants included)
Disease due to Coronaviridae (descendants included)
Coronavirus infection (descendants included)
Hypertensive disorder (descendants included)
Disease caused by 2019-nCoV (descendants included)
Disease due to Coronaviridae (descendants included)
Coronavirus infection (descendants included)
Hypertensive disorder (descendants included)
Disease caused by 2019-nCoV (descendants included)
Disease due to Coronaviridae (descendants included)
Coronavirus infection (descendants included)
Hypertensive disorder (descendants included)
Disease caused by 2019-nCoV (descendants included)
Disease due to Coronaviridae (descendants included)
Coronavirus infection (descendants included)
Hypertensive disorder (descendants included)
Disease caused by 2019-nCoV (descendants included)
Disease due to Coronaviridae (descendants included)
Coronavirus infection (descendants included)
Hypertensive disorder (descendants included)
Disease caused by 2019-nCoV (descendants included)
Disease due to Coronaviridae (descendants included)
Coronavirus infection (descendants included)
Hypertensive disorder (descendants included)
Disease caused by 2019-nCoV (descendants included)
Disease due to Coronaviridae (descendants included)
Coronavirus infection (descendants included)
Hypertensive disorder (descendants included)
Disease caused by 2019-nCoV (descendants included)
Disease due to Coronaviridae (descendants included)
Coronavirus infection (descendants included)
Hypertensive disorder (descendants included)
Atypical pneumonia (descendants included)
Pneumonia (descendants included)
Acute respiratory distress syndrome (descendants included)
Acute respiratory failure (descendants included)
Acute kidney injury due to circulatory failure
Acute kidney injury due to hypovolemia
Acute kidney injury due to sepsis
Acute kidney injury stage 1
Acute kidney injury stage 2
Acute kidney injury stage 3
Acute nephropathy (descendants included)
Acute kidney injury due to acute tubular necrosis due to sepsis (descendants included)
Acute kidney injury due to sepsis (descendants included)
Clinical sepsis (descendants included)
Menosepsis (descendants included)
Miscarriage with septic shock (descendants included)
Postprocedural intra-abdominal sepsis (descendants included)
Puerperal septicemia - delivered with postnatal complication (descendants included)
Sepsis (descendants included)
Sepsis syndrome (descendants included)
Sepsis-associated encephalopathy (descendants included)
Sepsis-associated lung injury (descendants included)
Sepsis-associated organ dysfunction (descendants included)
Septic shock (descendants included)
Systemic inflammatory response syndrome (descendants included)
Transient neonatal neutropenia due to neonatal bacterial sepsis (descendants included)
Dependence on ventilator (descendants included)
Myocardial infarction (descendants included)
Brainstem death (descendants included)
Cardiac arrest (descendants included)
Sudden cardiac death (descendants included)
Cerebral artery occlusion
Cerebral embolism
Cerebral infarction (descendants included)
Cerebral thrombosis
Cerebral hemorrhage
Intracranial hemorrhage
Spontaneous cerebellar hemorrhage
Spontaneous cerebral hemorrhage
Spontaneous hemorrhage of cerebral hemisphere
Spontaneous subarachnoid hemorrhage
Subarachnoid hemorrhage
Heart failure (descendants included)
Hypertensive disorder (descendants included)
Hypertensive disorder (descendants included)
Hypertensive disorder (descendants included)
Hypertensive disorder (descendants included)
Hypertensive disorder (descendants included)
Hypertensive disorder (descendants included)
Hypertensive disorder (descendants included)
Hypertensive disorder (descendants included)
Hypertensive disorder (descendants included)
Hypertensive disorder (descendants included)
Hypertensive disorder (descendants included)
Hypertensive disorder (descendants included)
Atypical pneumonia (descendants included)
Pneumonia (descendants included)
Atypical pneumonia (descendants included)
Pneumonia (descendants included)
Acute respiratory distress syndrome (descendants included)
Acute respiratory failure (descendants included)
Acute kidney injury due to circulatory failure
Acute kidney injury due to hypovolemia
Acute kidney injury due to sepsis
Acute kidney injury stage 1
Acute kidney injury stage 2
Acute kidney injury stage 3
Acute nephropathy (descendants included)
Acute kidney injury due to acute tubular necrosis due to sepsis (descendants included)
Acute kidney injury due to sepsis (descendants included)
Clinical sepsis (descendants included)
Menosepsis (descendants included)
Miscarriage with septic shock (descendants included)
Postprocedural intra-abdominal sepsis (descendants included)
Puerperal septicemia - delivered with postnatal complication (descendants included)
Sepsis (descendants included)
Sepsis syndrome (descendants included)
Sepsis-associated encephalopathy (descendants included)
Sepsis-associated lung injury (descendants included)
Sepsis-associated organ dysfunction (descendants included)
Septic shock (descendants included)
Systemic inflammatory response syndrome (descendants included)
Transient neonatal neutropenia due to neonatal bacterial sepsis (descendants included)
Disease caused by severe acute respiratory syndrome coronavirus 2 (descendants included)
Emergency use of U07.1 | Disease caused by severe acute respiratory syndrome coronavirus 2
Emergency use of U07.1 | Disease caused by severe acute respiratory syndrome coronavirus 2
Novel coronavirus infection
Other coronavirus as the cause of diseases classified elsewhere
Provisional assignment of new diseases or emergency use
Disease caused by severe acute respiratory syndrome coronavirus 2 (descendants included)
Emergency use of U07.1 | Disease caused by severe acute respiratory syndrome coronavirus 2
Emergency use of U07.1 | Disease caused by severe acute respiratory syndrome coronavirus 2
Novel coronavirus infection
Other coronavirus as the cause of diseases classified elsewhere
Provisional assignment of new diseases or emergency use
Febrile convulsion (descendants included)
Fever (descendants included)
Cough (descendants included)
Sputum finding (descendants included)
Acute respiratory distress (descendants included)
Dyspnea (descendants included)
Muscle pain (descendants included)
Fatigue (descendants included)
Malaise (descendants included)
Malaise and fatigue (descendants included)
Malaise and fatigue (descendants included)
Malaise and fatigue (descendants included)
Other malaise and fatigue (descendants included)
Other malaise and fatigue (descendants included)
Atypical pneumonia (descendants included)
Pneumonia (descendants included)
Suspected case of COVID-19 (machine translation)
Suspected coronavirus infection
Myocardial infarction (descendants included)
Brainstem death (descendants included)
Cardiac arrest (descendants included)
Sudden cardiac death (descendants included)
Cerebral artery occlusion
Cerebral embolism
Cerebral infarction (descendants included)
Cerebral thrombosis
Cerebral hemorrhage
Intracranial hemorrhage
Subarachnoid hemorrhage
Heart failure (descendants included)

Results

OHDSI COVID-19 Studyathon: ICARIUS - Susceptibility study

Source Code:

Covid19Icarius, Programming Language: R

Databases:

  
    
{
  "@graph": [
    {
      "@id": "concept:1335471",
      "@type": "schema:Drug",
      "code": {
        "@type": "schema:MedicalCode",
        "codeValue": "18867",
        "codingSystem": "RxNorm"
      },
      "identifier": "1335471",
      "name": "benazepril"
    },
    {
      "@id": "concept:1340128",
      "@type": "schema:Drug",
      "code": {
        "@type": "schema:MedicalCode",
        "codeValue": "1998",
        "codingSystem": "RxNorm"
      },
      "identifier": "1340128",
      "name": "captopril"
    },
    {
      "@id": "concept:19050216",
      "@type": "schema:Drug",
      "code": {
        "@type": "schema:MedicalCode",
        "codeValue": "21102",
        "codingSystem": "RxNorm"
      },
      "identifier": "19050216",
      "name": "cilazapril"
    },
    {
      "@id": "concept:1341927",
      "@type": "schema:Drug",
      "code": {
        "@type": "schema:MedicalCode",
        "codeValue": "3827",
        "codingSystem": "RxNorm"
      },
      "identifier": "1341927",
      "name": "enalapril"
    },
    {
      "@id": "concept:1342001",
      "@type": "schema:Drug",
      "code": {
        "@type": "schema:MedicalCode",
        "codeValue": "3829",
        "codingSystem": "RxNorm"
      },
      "identifier": "1342001",
      "name": "enalaprilat"
    },
    {
      "@id": "concept:1363749",
      "@type": "schema:Drug",
      "code": {
        "@type": "schema:MedicalCode",
        "codeValue": "50166",
        "codingSystem": "RxNorm"
      },
      "identifier": "1363749",
      "name": "fosinopril"
    },
    {
      "@id": "concept:45775539",
      "@type": "schema:Drug",
      "code": {
        "@type": "schema:MedicalCode",
        "codeValue": "1546393",
        "codingSystem": "RxNorm"
      },
      "identifier": "45775539",
      "name": "fosinoprilat"
    },
    {
      "@id": "concept:19122327",
      "@type": "schema:Drug",
      "code": {
        "@type": "schema:MedicalCode",
        "codeValue": "60245",
        "codingSystem": "RxNorm"
      },
      "identifier": "19122327",
      "name": "imidapril"
    },
    {
      "@id": "concept:1308216",
      "@type": "schema:Drug",
      "code": {
        "@type": "schema:MedicalCode",
        "codeValue": "29046",
        "codingSystem": "RxNorm"
      },
      "identifier": "1308216",
      "name": "lisinopril"
    },
    {
      "@id": "concept:1310756",
      "@type": "schema:Drug",
      "code": {
        "@type": "schema:MedicalCode",
        "codeValue": "30131",
        "codingSystem": "RxNorm"
      },
      "identifier": "1310756",
      "name": "moexipril"
    },
    {
      "@id": "concept:45775374",
      "@type": "schema:Drug",
      "code": {
        "@type": "schema:MedicalCode",
        "codeValue": "1546358",
        "codingSystem": "RxNorm"
      },
      "identifier": "45775374",
      "name": "moexiprilat"
    },
    {
      "@id": "concept:1373225",
      "@type": "schema:Drug",
      "code": {
        "@type": "schema:MedicalCode",
        "codeValue": "54552",
        "codingSystem": "RxNorm"
      },
      "identifier": "1373225",
      "name": "perindopril"
    },
    {
      "@id": "concept:45775544",
      "@type": "schema:Drug",
      "code": {
        "@type": "schema:MedicalCode",
        "codeValue": "1546400",
        "codingSystem": "RxNorm"
      },
      "identifier": "45775544",
      "name": "perindoprilat"
    },
    {
      "@id": "concept:1331235",
      "@type": "schema:Drug",
      "code": {
        "@type": "schema:MedicalCode",
        "codeValue": "35208",
        "codingSystem": "RxNorm"
      },
      "identifier": "1331235",
      "name": "quinapril"
    },
    {
      "@id": "concept:45775375",
      "@type": "schema:Drug",
      "code": {
        "@type": "schema:MedicalCode",
        "codeValue": "1546359",
        "codingSystem": "RxNorm"
      },
      "identifier": "45775375",
      "name": "quinaprilat"
    },
    {
      "@id": "concept:1334456",
      "@type": "schema:Drug",
      "code": {
        "@type": "schema:MedicalCode",
        "codeValue": "35296",
        "codingSystem": "RxNorm"
      },
      "identifier": "1334456",
      "name": "ramipril"
    },
    {
      "@id": "concept:45775527",
      "@type": "schema:Drug",
      "code": {
        "@type": "schema:MedicalCode",
        "codeValue": "1546377",
        "codingSystem": "RxNorm"
      },
      "identifier": "45775527",
      "name": "ramiprilat"
    },
    {
      "@id": "concept:19040051",
      "@type": "schema:Drug",
      "code": {
        "@type": "schema:MedicalCode",
        "codeValue": "36908",
        "codingSystem": "RxNorm"
      },
      "identifier": "19040051",
      "name": "spirapril"
    },
    {
      "@id": "concept:1342439",
      "@type": "schema:Drug",
      "code": {
        "@type": "schema:MedicalCode",
        "codeValue": "38454",
        "codingSystem": "RxNorm"
      },
      "identifier": "1342439",
      "name": "trandolapril"
    },
    {
      "@id": "concept:45775529",
      "@type": "schema:Drug",
      "code": {
        "@type": "schema:MedicalCode",
        "codeValue": "1546379",
        "codingSystem": "RxNorm"
      },
      "identifier": "45775529",
      "name": "trandolaprilat"
    },
    {
      "@id": "concept:19102107",
      "@type": "schema:Drug",
      "code": {
        "@type": "schema:MedicalCode",
        "codeValue": "39990",
        "codingSystem": "RxNorm"
      },
      "identifier": "19102107",
      "name": "zofenopril"
    },
    {
      "@id": "concept:40235485",
      "@type": "schema:Drug",
      "code": {
        "@type": "schema:MedicalCode",
        "codeValue": "1091643",
        "codingSystem": "RxNorm"
      },
      "identifier": "40235485",
      "name": "azilsartan"
    },
    {
      "@id": "concept:1351557",
      "@type": "schema:Drug",
      "code": {
        "@type": "schema:MedicalCode",
        "codeValue": "214354",
        "codingSystem": "RxNorm"
      },
      "identifier": "1351557",
      "name": "candesartan"
    },
    {
      "@id": "concept:1346686",
      "@type": "schema:Drug",
      "code": {
        "@type": "schema:MedicalCode",
        "codeValue": "83515",
        "codingSystem": "RxNorm"
      },
      "identifier": "1346686",
      "name": "eprosartan"
    },
    {
      "@id": "concept:1347384",
      "@type": "schema:Drug",
      "code": {
        "@type": "schema:MedicalCode",
        "codeValue": "83818",
        "codingSystem": "RxNorm"
      },
      "identifier": "1347384",
      "name": "irbesartan"
    },
    {
      "@id": "concept:1367500",
      "@type": "schema:Drug",
      "code": {
        "@type": "schema:MedicalCode",
        "codeValue": "52175",
        "codingSystem": "RxNorm"
      },
      "identifier": "1367500",
      "name": "losartan"
    },
    {
      "@id": "concept:40226742",
      "@type": "schema:Drug",
      "code": {
        "@type": "schema:MedicalCode",
        "codeValue": "321064",
        "codingSystem": "RxNorm"
      },
      "identifier": "40226742",
      "name": "olmesartan"
    },
    {
      "@id": "concept:1317640",
      "@type": "schema:Drug",
      "code": {
        "@type": "schema:MedicalCode",
        "codeValue": "73494",
        "codingSystem": "RxNorm"
      },
      "identifier": "1317640",
      "name": "telmisartan"
    },
    {
      "@id": "concept:1308842",
      "@type": "schema:Drug",
      "code": {
        "@type": "schema:MedicalCode",
        "codeValue": "69749",
        "codingSystem": "RxNorm"
      },
      "identifier": "1308842",
      "name": "valsartan"
    },
    {
      "@id": "concept:1316354",
      "@type": "schema:Drug",
      "code": {
        "@type": "schema:MedicalCode",
        "codeValue": "1369",
        "codingSystem": "RxNorm"
      },
      "identifier": "1316354",
      "name": "bendroflumethiazide"
    },
    {
      "@id": "concept:1395058",
      "@type": "schema:Drug",
      "code": {
        "@type": "schema:MedicalCode",
        "codeValue": "2409",
        "codingSystem": "RxNorm"
      },
      "identifier": "1395058",
      "name": "chlorthalidone"
    },
    {
      "@id": "concept:974166",
      "@type": "schema:Drug",
      "code": {
        "@type": "schema:MedicalCode",
        "codeValue": "5487",
        "codingSystem": "RxNorm"
      },
      "identifier": "974166",
      "name": "hydrochlorothiazide"
    },
    {
      "@id": "concept:978555",
      "@type": "schema:Drug",
      "code": {
        "@type": "schema:MedicalCode",
        "codeValue": "5764",
        "codingSystem": "RxNorm"
      },
      "identifier": "978555",
      "name": "indapamide"
    },
    {
      "@id": "concept:907013",
      "@type": "schema:Drug",
      "code": {
        "@type": "schema:MedicalCode",
        "codeValue": "6916",
        "codingSystem": "RxNorm"
      },
      "identifier": "907013",
      "name": "metolazone"
    },
    {
      "@id": "concept:19010493",
      "@type": "schema:Drug",
      "code": {
        "@type": "schema:MedicalCode",
        "codeValue": "11371",
        "codingSystem": "RxNorm"
      },
      "identifier": "19010493",
      "name": "xipamide"
    },
    {
      "@id": "concept:1332418",
      "@type": "schema:Drug",
      "code": {
        "@type": "schema:MedicalCode",
        "codeValue": "17767",
        "codingSystem": "RxNorm"
      },
      "identifier": "1332418",
      "name": "amlodipine"
    },
    {
      "@id": "concept:19089969",
      "@type": "schema:Drug",
      "code": {
        "@type": "schema:MedicalCode",
        "codeValue": "233603",
        "codingSystem": "RxNorm"
      },
      "identifier": "19089969",
      "name": "clevidipine"
    },
    {
      "@id": "concept:1353776",
      "@type": "schema:Drug",
      "code": {
        "@type": "schema:MedicalCode",
        "codeValue": "4316",
        "codingSystem": "RxNorm"
      },
      "identifier": "1353776",
      "name": "felodipine"
    },
    {
      "@id": "concept:1326012",
      "@type": "schema:Drug",
      "code": {
        "@type": "schema:MedicalCode",
        "codeValue": "33910",
        "codingSystem": "RxNorm"
      },
      "identifier": "1326012",
      "name": "isradipine"
    },
    {
      "@id": "concept:19004539",
      "@type": "schema:Drug",
      "code": {
        "@type": "schema:MedicalCode",
        "codeValue": "28382",
        "codingSystem": "RxNorm"
      },
      "identifier": "19004539",
      "name": "lacidipine"
    },
    {
      "@id": "concept:19015802",
      "@type": "schema:Drug",
      "code": {
        "@type": "schema:MedicalCode",
        "codeValue": "135056",
        "codingSystem": "RxNorm"
      },
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